Tissue Lysates
Cayman Chemical 16-carboxy MItragynIn 1mg
An analytical reference standard categorized as an opioid; a metabolite of mitragynine; intended for research and forensic applications
Cayman Chemical 2-LInoleoyl Glycerol 1mg
A congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group that potentiates the activity of other endocannabinoids, including 2-AG; this “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to rapidly reduce endocannabinoid levels following release
Cayman Chemical Mer-NF5003F 1mg
A sesquiterpene with diverse biological activities; inhibits AMV protease (IC50 = 7.8 µM); inhibits ST6N , ST3O, and ST3N (IC50s = 0.61, 6.7, and 10 UG/ml, respectively), as well as fucosyltransferase (IC50 = 11.3 UG/ml); active against HSV-1 in vitro (IC50 = 4.32 UG/ml); active against the multidrug-resistant P. falciparum strain K1 (IC50 = 0.85 UG/ml)
Cayman Chemical N-desethyl AmodIaquInhydro 1mg
A primary, active metabolite of the antimalarial compound aminodiaquine
Cayman Chemical 7-nor-7-carboxy CnabIdI 1mg
An analytical reference standard categorized as a phytocannabinoid metabolite; a metabolite of cannabidiol; intended for research and forensic applications
Cayman Chemical SynthetIc MaytnsIn 1mg
An ansa macrolide with anticancer activity; inhibits the growth of L1210, L-5178-Y, and P388 murine leukemia cells (EC50s = 0.6, 12, and 1.5 nM, respectively); inhibits erythrocyte and brain tubulin polymerization at 20 µM; increases survival in a P388 murine leukemia model from 0.021-0.1 mg/kg; has also been used in the synthesis of cytotoxic payload moieties of ADCs
Cayman Chemical C18 PhytoceramIde-d3t18 01 1mg
An internal standard for the quantification of C18 phytoceramide by GC- or LC-MS
Cayman Chemical SynthetIc GW 9662 1mg
The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.
Cayman Chemical 1 3-DIeIcosenoyl Glycerol 1mg
A diacylglyerol containing 11(Z)-eicosenoic acid at the sn-1 and sn-3
Cayman Chemical GLP-2ratrIfluoroacetate 1mg
A gut peptide hormone agonist of GLP-2R; increases cAMP levels in COS cells expressing GLP-2R (EC50 = 0.58 nM); produced by enteroendocrine L cells of the small and large intestine and in the hypothalamus; increases small bowel weight by 50% and increases villus height and crypt cell proliferation in the small intestine of mice (43.75 μg twice per day for 10 days); reduces two-hour food intake in rats by 37% (10 μg); secretion is stimulated by dietary carbohydrates, glucose, dextrin, and oils rich in polyunsaturated or monounsaturated fatty acids